Calvin Kuo Laboratory @ Stanford University



May 2017 - The Kuo lab publishes two manuscripts in Nature with Chris Garcia’s lab on Wnt pathway regulation of intestinal stem cells and liver zonation/proliferation. In one study, from lead author and Gastroenterology Fellow Kelley Yan, postdoctoral fellows Leo Chang and Amanda Mah, graduate student Luis Chia, and 10X Genomics, Wnt and Rspo ligands are shown to have distinct but cooperative roles on Lgr5+ intestinal stem cell regulation. In the other study, Leo Chang and Xingnan Li from the Kuo lab assisted the Garcia lab to characterize their artificial bioengineered Wnt surrogates and demonstrate regulation of liver biology.
News coverage: CIRM, Yahoo, Stanford

March 2017 - Postdoctoral fellow Leo Chang and MD/PhD student Michael Mancuso describe in the journal Nature Medicine how the endothelial receptor Gpr124 limits brain blood vessel leakage after stroke or brain tumors (Nature Medicine LINK). (F1000 Recommended LINK)

April 2016 - Postdoctoral Fellow, Ameen Salahudeen, receives Fellowship from the A.P. Giannini Foundation and is named the ECOG Paul Carbone Fellowship Awardee.

March 2016 - Undergraduate Jeffrey Kwong receives Stanford University Sterling Prize.

January 2016 - Calvin Elected as AAAS Fellow and member of the American Academy of Physicians.

August 2015 - Calvin named Maureen Lyles D'Ambrogio Professor of Medicine at Stanford Medical School.

March 2015 - Calvin named Vice Chair of the Department of Medicine at Stanford Medical School.

February 2015 - Summer student Steven Wang named as one of 40 finalists nationwide for Intel Science Talent Search.

January 2015 - Postdoctral Fellow Junlei Chang receives American Heart Association Postdoctoral Fellowship.

July 2014 - Research Associate Xingnan Li, Oncology Fellow Lincoln Nadauld, and Postdoctoral Fellows Michael Cantrell, Paul Rack and JT Neal publish in Nature Medicine first in vitro onocgenic transformation of primary colon, stomach and pancreatic tissue to adenocarcinoma, exploiting organoid culture methods. They also use colon organoids to validate miR-483 as a novel colon cancer oncogene (Nature Medicine LINK, PODCAST).
News Coverage: STANFORD, NCI

October 2013 - MD/PhD students Kevin Wei and Lisa McGinnis and postdoctoral fellow Stephanie Piecewicz in collaboration with Amato Giaccias lab publish back-to-back letters in Nature Medicine describing that hypoxia/HIF2 signaling sensitizes liver insulin signaling by inducing hepatic expression of IRS2. These studies also show that VEGF inhibition induces the HIF2/IRS2 pathway and in fact that either VEGF inhibition or HIF2 activation effective treats mouse models of diabetes. (Nature Medicine LINK 1 LINK 2).

May 2013 - Oncology Fellow Lincoln Nadauld receives NIH K08 Award from NCI and also a ASCO Young Investigator Award.

June 2012 - Gastroenterology Fellow Kelley Yan receives NIH K08 Award from NIDDK and Burroughs Wellcome Foundation Career Award for Medical Scientists.

June 2012 - Calvin named Co-lead of the Cancer Biology Program at the Stanford Cancer Center.